Mesalazine associated nephrogenic diabetes insipidus presenting as weight loss.
نویسندگان
چکیده
Nephrotoxicity in association with 5-aminosalicylic acid therapy is well recognised. In this patient the nephrotoxicity only became apparent after severe weight loss had occurred in association with nephrogenic diabetes insipidus. The patient aged 26 with ulcerative colitis received resin coated mesalazine (Asacol) 1200 mg/day and lost 12 kg in weight over a four month period, only complaining of thirst towards the end of this period.
منابع مشابه
Proximal tubular dysfunction associated with tenofovir and didanosine causing Fanconi syndrome and diabetes insipidus: a report of 3 cases.
We report 3 cases of patients with HIV/AIDS in whom Fanconi syndrome and nephrogenic diabetes insipidus developed secondary to use of an antiretroviral regimen containing tenofovir disoproxil fumarate and didanosine. These patients presented with a history of polydipsia, polyuria, weight loss, anorexia, and wasting. Interestingly, 1 patient was not taking protease inhibitors. This response is a...
متن کاملHypernatremic dehydration, diabetes insipidus, and cerebral venous sinus thrombosis in a neonate: a case report
Background In breast-fed neonates, hypernatremia may occur from inadequate breast milk production, central or nephrogenic diabetes insipidus, gastroenteritis, or salt poisoning. Hypernatremic dehydration is a known risk factor for cerebral sinus thrombosis and death. We report a breastfed neonate with hypernatremic dehydration, diabetes insipidus, cerebral sinus thrombosis, and disseminated int...
متن کاملBartter Syndrome Type 1 Presenting as Nephrogenic Diabetes Insipidus
Bartter syndrome (BS) type 1 (OMIM #601678) is a hereditary salt-losing renal tubular disorder characterized by hypokalemic metabolic alkalosis, hypercalciuria, nephrocalcinosis, polyuria, recurrent vomiting, and growth retardation. It is caused by loss-of-function mutations of the SLC12A1 gene, encoding the furosemide-sensitive Na-K-Cl cotransporter. Recently, a phenotypic variability has been...
متن کاملLithium-induced nephrogenic diabetes insipidus.
BACKGROUND Lithium can cause nephrogenic diabetes insipidus in up to 20 to 40 percent of patients currently taking the medication, and a subset of these patients will have a persistent concentrating defect long after lithium is discontinued. They are at risk for serious hypernatremia when fluid intake is restricted for any reason. METHODS MEDLINE as used to search the key words "nephrogenic d...
متن کاملPersistent nephrogenic diabetes insipidus, tubular proteinuria, aminoaciduria, and parathyroid hormone resistance following longterm lithium administration.
We report a patient who developed persistent nephrogenic diabetes insipidus associated with renal tubular acidosis, renal resistance to parathyroid hormone, aminoaciduria and proximal tubule pattern proteinuria in the presence of a reduced glomerular filtration rate (19-24 ml/min). A review of the previous reports of persistent nephrogenic diabetes insipidus revealed that in all patients the gl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Gut
دوره 33 4 شماره
صفحات -
تاریخ انتشار 1992